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Daniel Durstewitz
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Email:
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daniel.durstewitz@plymouth.ac.uk |
Contact:
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Centre for Theoretical and Computational Neuroscience
University of Plymouth
A220 Portland Square
Plymouth
PL4 8AA
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Jobs |
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Research Interests &
Current Projects
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The biophysics of cognition
In the brain, unlike conventional computers, cognitive
processes like memory and perception are tightly interlinked with their
physical substrate. Understanding the biophysical mechanisms behind the
repertoire of dynamical phenomena the nervous system can generate is
therefore an essential part for understanding brain function in general.
We gain insight into the material basis of cognition by developing
biophysically realistic computer models that can account for
neurophysiological observations and relate them to cognitive function,
by probing neural networks 'in a dish', and analyzing neurophysiological
data with the help of methods from nonlinear dynamics and statistics.
Current research projects focus primarily on the biophysical mechanisms
and neural dynamics underlying the organization of behavior in time,
which is based on cognitive ingredients like the ability to keep
information 'online' about the recent history of events and their
temporal structure (working & short-term memory), and the ability to use
that information to predict forthcoming events.
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Lab Members
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- Thomas Gabriel (Ph.D. student)
- Ullrich Bartsch (Ph.D. student)
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Selected
Publications
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Durstewitz D & Gabriel T
(2006) Dynamical basis of irregular spiking in NMDA-driven
prefrontal cortex neurons. Cerebral Cortex.
Code for simulations in this
publication.

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Durstewitz D & Seamans JK
(2006) Beyond bistability: Biophysics and temporal dynamics of
working memory. Neuroscience 139: 119-133.

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Durstewitz
D (2004). Neural representation of interval time. Neuroreport 15:
745-749.
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Durstewitz
D (2003), Self-Organizing Neural Integrator Predicts Interval Times
through Climbing Activity. J. Neurosci. 23: 5342-5353.
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Durstewitz,
D., & Seamans, J.K. (2002) The computational role of dopamine D1
receptors in working memory. Neural Networks 15, 561-572.
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Seamans
JK, Gorelova N, Durstewitz D, Yang CR (2001), Bidirectional dopamine
modulation of GABAergic inhibition in prefrontal cortical pyramidal
neurons. J. Neurosci. 21: 3628-3638.
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Seamans
JK, Durstewitz D, Christie B, Sejnowski TJ, Stevens CF (2001), Dopamine
D1/D5 receptor modulation of excitatory synaptic inputs to layer V
prefrontal cortex neurons. Proc. Natl. Acad. Sci. USA 98:301-306.
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Durstewitz
D, Seamans JK, Sejnowski TJ (2000), Neurocomputational models of working
memory. Nat. Neurosci. 3 supp., 1184-1191.
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Durstewitz
D, Seamans JK, Sejnowski TJ (2000), Dopamine-mediated stabilization of
delay-period activity in a network model of prefrontal cortex. J.
Neurophysiol. 83, 1733-1750.
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Durstewitz,
D., Kelc, M. and Güntürkün, O. (1999), A neurocomputational theory of
the dopaminergic modulation of working memory functions, J. Neurosci.,
19, 2807-2822.
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Durstewitz,
D., Kröner, S. and Güntürkün, O. (1999), The dopaminergic
innervation of the avian telencephalon, Progr. Neurobiol., 59,
161-195.
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Durstewitz D, Kröner
S, Hemmings HC, Güntürkün O (1998) The dopaminergic innervation
of the pigeon telencephalon: distribution of DARPP-32 and co-occurrence
with glutamate decarboxylase and tyrosine hydroxylase. Neuroscience 83,
763-779.

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